Melatonin exerts its biological effects by combining with G protein-coupled receptors with pharmacological specificity, high affinity. 褪黑激素通过与药理学特异的高亲和性G-蛋白偶联受体相结合来发挥其生物学功能。
This result demonstrated the feasibility of efficient separation and identification of active components by combining molecular imprinting affinity liquid chromatography ( LC) with mass spectrometry ( MS). 实验结果证明了通过分子烙印亲和色谱与质谱联用方法,快速有效地对中草药活性成分分离鉴定是可能的。
METHODS Combining estrone with basic side chain on 3-position, four compounds were synthesized, two of them have not been reported, and the activities of compounds were measured by their affinity to uterus. 方法以雌酚酮为原料,在3位与碱性侧链相连,合成了4个化合物,其中2个未见文献报道,并进行亲子宫和抗子宫活性测定。